Extracellular Nicotinamide Phosphoribosyltransferase Is a Component of the Senescence-Associated Secretory Phenotype

Cellular senescence is a stress or damage response by which a cell adopts of state of essentially permanent proliferative arrest, coupled to the secretion of a number of biologically active molecules.This senescence-associated secretory phenotype (SASP) underlies many of the degenerative and regenerative aspects of cellular senescence - including p

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Configuration Synthesis of Novel Hybrid Transmission Systems Using a Combination of a Ravigneaux Gear Train and a Simple Planetary Gear Train

Thirty-two novel hybrid transmissions consisting of a Ravigneaux gear train and a single planetary gear train are synthesized using a creative design methodology based on graph-theory and the lever analogy method.The design process commences by identifying an existing transmission configuration which meets all of the design requirements.The chosen

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